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Title   TPA 로 야기된 HL - 60 세포의 기질부착 저해작용을 이용한 Protein Kinase C 저해 생약의 탐색 ( Screening of Protein Kinase C - inhibiting hervs using TPA - induced Adherence of HL - 60 Ceel )
Publicationinfo   1993 Jan; 025(01): 9-15.
Key_word   Protein kinase C, HL-60 cell adhesion, Inhibitory effects of raw drugs
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Abstract   Thirty-five kinds of herbal drugs, believed to be active for treatment of tumors, were selected as the experimental materials for observing their effects on TPA-induced adherence of HL-60 cell and activity of protein kinase C. They were extracted with ethyl ether(E) and ethyl acetate(EA), methanol(M) in sequence. Among the extracts, SoPhorae Flos(EA), Paeoniae Radix (EA), Equisetum hiemale(EA), Phellodendri Cortex(E, EA), mori Cortex radicis(EA), Ferula assafoetida(E, EA), SoPhora subprostrata(EA, M) and Cnidium monnieri(E) inhibited the TPA-in- duced adherence of HL-60 cell more than 50% and Sophor#ue Flos(E, EA, M), Paeoniae Radixg(EA, M), Equisetum hiemale(E), Phellodenri Cortex(E, M), Mori Cortex radicis(M), Ferula assafoeti- da(M), SoPhora sudprostrata(EA, M), Cnidium monnieri(M) and Artemisia argyi(M) showed in- hibiting effects on the activity of protein kinase C more than 50%. The extracts showing good inhibiting effects on the adherence and enzyme activity were Sophorae Flos(EA), Paeoniae Radix(EA), Phelladendri Cortex(E), Sophora subsprostrata(EA) and Equisetum hiemale(EA).
저 자   김선희(Seon Hee Kim),안종석(Jong Suck Ahn),김삼용(Sam Yong Kim),유관희(Kwan Hee Yu),안병준(Byung Zun Ahn)